92. Mechanisms Underlying Agonist-Induced Desensitization of Oxytocin Receptor in Neurons

Oxytocin serves a critical role in the brain as a neuromodulator regulating social and other affective behavior. Disturbance in oxytocin signaling has been implicated in autism spectrum disorder and clinical trials are ongoing to test the efficacy of administered oxytocin in relieving social deficits. However, the signaling and regulatory mechanisms that are evoked following activation of oxytocin receptor (OXTR) in neurons remain largely unexplored.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research