430. Multimodal Evidence of Mediodorsal Thalamus-Prefrontal Circuit Dysfunctions in Clinical High-Risk for Psychosis: Findings From a Combined 7T fMRI, MRSI and Sleep High-Density EEG Study

Reduced mediodorsal thalamus-dorsolateral prefrontal cortex (MD-Thal/DLPFC) resting-state functional MRI (rs-fMRI) connectivity and decreased thalamically-generated sleep spindles in DLPFC have been reported in patients with Schizophrenia (SCZ). However, evidence of these alterations, including their relationships with underlying neurotransmission, in clinical high-risk for psychosis (CHR), where early detection can facilitate timely interventions, is lacking.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research