455. AI-Derived Neuroanatomical Subtypes of Schizophrenia and Their Expression During Disease Onset and in Unaffected Siblings

Schizophrenia (SCZ) has a heterogeneous presentation of symptoms, clinical outcomes and response to treatment, which suggest the presence of different subtypes. Heterogeneity likely hinders the understanding of psychosis neurobiology and prevents progress from symptom-based diagnoses to biology-based diagnoses. We used a data-driven, deep-learning analysis of MRI data to examine neuroanatomical subtypes of psychotic disorders. We also examine the extent to which the neuroanatomical subtypes were expressed in first-episode patients (FEP) and in unaffected siblings of patients with SCZ (SIBS).

Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Mathilde Antoniades, Zhijian Yang, Ganesh Chand, Hugo Schnack, Russell T. Shinohara, Antonia N. Kaczkurkin, Tyler M. Moore, Raquel E. Gur, Theodore D. Satterthwaite, Marta Di Forti, Simone Ciufolini, Marcus V. Zanetti, Benedicto Crespo-Facorro, Geraldo F. Source Type: research