Determining the relationship of p16INK4a and additional molecular markers of aging with clinical frailty in hematologic malignancy

ConclusionsOur pilot data suggest that multiple blood-based aging biomarkers have potential to identify frailty in older adults with HM.Implications for Cancer SurvivorsWe developed the I2 index to quantify impairments across geriatric domains and discovered that PBTL p16, Hannum, PhenoAge, and DunedinPACE are promising indicators of frailty in HM.
Source: Journal of Cancer Survivorship - Category: Cancer & Oncology Source Type: research