Adenylate kinase 4 promotes neuronal energy metabolism and mitophagy in early cerebral ischemia via Parkin/PKM2 pathway

In conclusion, our data demonstrate that AK4/ Parkin /PKM axis prevents cerebral ischemia damage via regulation of neuronal energy metabolism model and mitophagy. AK4 was a new target for intervention of early ischemic neuron injury.PMID:38670251 | DOI:10.1016/j.expneurol.2024.114798

Source: Experimental Neurology - April 26, 2024 Category: Neurology Authors: Yunxue Zhong Bingbing Jia Cong Xie Hu Linghui Zijun Liao Wenlan Liu Yuan Zhang Guodong Huang Source Type: research