Angiotensin Receptor-Neprilysin Inhibitor Suppresses Renin-Angiotensin-Aldosterone System Activation After Cardiac Surgery Using Cardiopulmonary Bypass

CONCLUSIONS: Sacubitril/valsartan administration was safe immediately after open heart surgery in patients without postoperative hypotension. It enhanced serum atrial natriuretic peptide concentrations and suppressed RAAS activation.PMID:38658351 | DOI:10.1253/circj.CJ-23-0879

Source: Circulation Journal - April 24, 2024 Category: Cardiology Authors: Joji Hoshino Shunsuke Saito Ikuko Shibasaki Toshimi Sairenchi Shohei Okubo Taiki Matsuoka Shotaro Hirota Shohei Yokoyama Yuta Kanazawa Masahiro Tezuka Yusuke Takei Go Tsuchiya Taisuke Konishi Koji Ogata Hirotsugu Fukuda Source Type: research