Chemical and activity investigation on metabolites from the endophytic fungus < em > Penicillium macrosclerotiorum < /em > isolated from < em > Ilex pubescens Hook. et Arn < /em >

Nat Prod Res. 2024 Apr 22:1-5. doi: 10.1080/14786419.2024.2337111. Online ahead of print.ABSTRACTPenicillium macrosclerotiorum was isolated for the first time from the leaves of Ilex pubescens Hook. et Arn (VSN-2022-03-18-001) and found to produce bioactive compounds. Seven compounds were obtained from the fermentation broth and mycelia of P. macrosclerotiorum and identified as palmitic acid (1), methyl 6-acetyl-5,7,8-trihydroxy-4-methoxy-2-naphthoate (2), ergosterol (3), daidzein (4), oleuropein (5), pedunculoside (6) and acteoside (7). Compounds 3, 4 and 7 exhibited antioxidant activity against diphenyl picryl hydrazinyl with IC50 values of 58.06, 2.58 and 12.01 µg/mL, respectively. Compounds 3, 5 and 7 exhibit inhibitory activity against Escherichia coli with MIC values of 0.78, 3.13 and 3.13 mg/mL, while compounds 2, 3, 4, 5, 6 and 7 exhibited inhibitory effect on Candida albicans with MIC values of 0.20, 0.20, 0.39, 0.63, 0.78 and 0.78 mg/mL, respectively. Furthermore, Compound 4 effectively inhibited HepG2 cells, showing an IC50 of 34.03 μg/mL.PMID:38646779 | DOI:10.1080/14786419.2024.2337111
Source: Natural Product Research - Category: Biochemistry Authors: Source Type: research