Emergence of OXA-48-producing < em > Klebsiella pneumoniae < /em > in Lithuania, 2023: a multi-cluster, multi-hospital outbreak

Euro Surveill. 2024 Apr;29(16):2400188. doi: 10.2807/1560-7917.ES.2024.29.16.2400188.ABSTRACTIn 2023, an increase of OXA-48-producing Klebsiella pneumoniae was noticed by the Lithuanian National Public Health Surveillance Laboratory. Whole genome sequencing (WGS) of 106 OXA-48-producing K. pneumoniae isolates revealed three distinct clusters of carbapenemase-producing K. pneumoniae high-risk clones, including sequence type (ST) 45 (n = 35 isolates), ST392 (n = 32) and ST395 (n = 28), involving six, six and nine hospitals in different regions, respectively. These results enabled targeted investigation and control, and underscore the value of national WGS-based surveillance for antimicrobial resistance.PMID:38639094 | PMC:PMC11027475 | DOI:10.2807/1560-7917.ES.2024.29.16.2400188

Source: Euro Surveill - April 19, 2024 Category: Infectious Diseases Authors: Paulius Grei čius Marius Linkevicius Jelena Razmuk Jekaterina Sinotova Erik Alm Olov Svartstr öm Valeria Bortolaia Egl ė Kudirkienė Louise Roer Rene S Hendriksen Gabija Tamoli ūnaitė Daniel Palm Dominique L Monnet Anke Kohlenberg Algirdas Gri škevi Source Type: research