In Vitro and in Vivo Study of a Photostable Quinone Compound with Enhanced Therapeutic Efficacy against Chagas Disease
In this study, we elucidated the structure of the light-induced degradation products of compound 2 and probed the correlation between the quinone ring's substituents and its susceptibility to light. Our findings led to the discovery of quinones with significantly enhanced light stability, some of which exhibiting antitrypanosomal activity. The most promising compound was evaluated for drug efficacy in a mouse model of Chagas disease, revealing where a notable reduction in blood parasitemia.PMID:38644164 | DOI:10.1248/cpb.c24-00116
Source: Chemical and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Yutaka Suto Nagisa Inoue Mohammed Suliman Omer Tagod Yoko Onizuka Tomoya Nobuta Mayumi Ishii Daniel Ken Inaoka Kayoko Kanamitsu Noriyuki Yamagiwa Junko Nakajima-Shimada Source Type: research