From "contraindicated" to "first line" - Current mechanistic insights beyond canonical β-receptor signaling

Curr Opin Pharmacol. 2024 Apr 17;76:102458. doi: 10.1016/j.coph.2024.102458. Online ahead of print.ABSTRACTβ-blockers are a solid pillar in the treatment of cardiovascular diseases. However, they are highly discussed regarding effectiveness for certain indications and side-effects. Even though there are up to 20 licensed compounds, only four are used for heart failure (HF) therapy. On the receptor level several key characteristics seem to influence the clinical outcome: subtype selectivity, antagonistic vs (inverse/biased) agonistic properties and -in particular- ancillary capacities. On a molecular level, divergent and novel signaling patterns are being identified and extra-cardiac effects on e.g. inflammation, metabolism and oxidative stress are highlighted. This review discusses different well-known and newly discovered characteristics that need to be considered for HF therapy and in the context of co-morbidities.PMID:38636195 | DOI:10.1016/j.coph.2024.102458
Source: Current Opinion in Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research