Transplant-associated Altered Mentation and Encephalopathy (TAME): A New Classification for Acute Neurocognitive Changes Associated with Hematopoietic Cell Transplantation from the ASTCT Committee on Practice Guidelines

Acute encephalopathy, manifesting clinically as delirium, is a common but often unrecognized complication of hematopoietic cell transplant (HCT). Delirium is found in patients of any age and observed after autologous or allogeneic HCT. While primarily studied during initial transplant hospitalizations among recipients of myeloablative conditioning, recent HCT investigations have identified delirium later posttransplant and among those who received reduced intensity conditioning. Acute encephalopathy can be driven by infectious complications, medications, tissue damage and/or organ dysfunction.

Source: Biology of Blood and Marrow Transplantation - April 23, 2024 Category: Hematology Authors: G. Meyers, J. Bubalo, E. Eckstrom, K. Winsnes, P.A. Carpenter, A. Artz, R.J. Lin Source Type: research