Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis

CONCLUSIONS: By identifying and integrating the most gene-rich single-cell subclusters of atherosclerosis to date with a coronary artery disease framework of GRNs, GRN39 was identified and independently validated as being critical for the transformation of contractile SMCs into an osteogenic phenotype promoting advanced-stage, symptomatic atherosclerosis.PMID:38639096 | DOI:10.1161/CIRCRESAHA.123.323184

Source: Circulation Research - April 19, 2024 Category: Cardiology Authors: Giuseppe Mocci Katyayani Sukhavasi Tiit Örd Sean Bankier Prosanta Singha Uma Thanigai Arasu Olayinka Oluwasegun Agbabiaje Petri M äkinen Lijiang Ma Chani J Hodonsky Redouane Aherrahrou Lars Muhl Jianping Liu Sonja Gustafsson Byambajav Byandelger Ying Wa Source Type: research