Genkwanin alleviates intervertebral disc degeneration via regulating ITGA2/PI3K/AKT pathway and inhibiting apoptosis and senescence

In conclusion, This study suggest that genkwanin inhibits inflammation in nucleus pulposus cells, promotes extracellular matrix remodeling, suppresses cellular senescence and apoptosis, through the ITGA2/PI3K/AKT, NF-κB and MAPK signaling pathways. These findings indicate that genkwanin may be a promising therapeutic candidate for IVDD.PMID:38640717 | DOI:10.1016/j.intimp.2024.112101

Source: International Immunopharmacology - April 19, 2024 Category: Allergy & Immunology Authors: Mengwei Li Xiaojun Yu Xin Chen Yongqiao Jiang Yunqian Zeng Ranyue Ren Mingbo Nie Ziyang Zhang Yuan Bao Hao Kang Source Type: research