EphB2 receptor promotes dermal fibrosis in systemic sclerosis

ConclusionOur data implicate TGF- β regulation of EphB2 overexpression and kinase-mediated forward signaling in the development of dermal fibrosis in SSc. EphB2 thus represents a potential new therapeutic target for SSc.

Source: Arthritis and Rheumatology - April 9, 2024 Category: Rheumatology Authors: Erika SA Egal, Severin Donald Kamdem, Masaaki Yoshigi, Ching ‐Chu Yang, Sarah Pellizzari, Ernest M Kameni, My N Helms, Shervin Assassi, Mark Henkemeyer, Tracy M Frech, Patrice N Mimche Tags: Full Length Source Type: research