Presynaptic density determined by SV2A PET is closely associated with postsynaptic metabotropic glutamate receptor 5 availability and independent of amyloid pathology in early cognitive impairment

CONCLUSIONS: Reductions in mGluR5 availability and synaptic density exhibit similar spatial patterns in AD and are closely linked.HIGHLIGHTS: Cognitively impaired patients exhibited lower mGluR5 availability and synaptic density in the medial temporal lobe than HCs. Reductions in mGluR5 availability and synaptic density exhibit similar spatial patterns in AD. Regional synaptic density was closely associated with regional mGluR5 availability. mGluR5 availability and synaptic loss partially mediated the relationship between amyloid deposition and global cognition. With further research, modulating mGluR5 availability might be a potential therapeutic strategy for improving synaptic function in AD.PMID:38634334 | DOI:10.1002/alz.13817

Source: The Journal of Alzheimers Association - April 18, 2024 Category: Psychiatry Authors: Jie Wang Qi Huang Kun He Junpeng Li Tengfei Guo Yang Yang Zengping Lin Songye Li Greet Vanderlinden Yiyun Huang Koen Van Laere Yihui Guan Qihao Guo Ruiqing Ni Binying Li Fang Xie Source Type: research