Exploring mitochondrial targeting: an innovative fluorescent probe reveals Nernstian potential and partitioning combination

This study introduces a paradigm-shifting approach to optimize mitochondrial targeting. Employing a new fluorescent probe strategy, we unravel a combined influence of both Nernst potential (Ψ) and partitioning (P) contributions. Through the synthesis of new benz[e]indolinium-derived probes, our findings redefine the landscape of mitochondrial localization by optimizing the efficacy of mitochondrial probe retention in primary cortical neurons undergoing normoxia and oxygen-glucose deprivation. This methodology not only advances our understanding of subcellular dynamics, but also holds promise for transformative applications in biomedical research and therapeutic development.PMID:38634835 | DOI:10.1039/d4cc01144a

Source: Chemical Communications - April 18, 2024 Category: Chemistry Authors: Javier Ord óñez-Hernández Daniela Ceballos- Ávila Fernando H Real Luis B Tovar-Y-Romo Arturo Jim énez-Sánchez Source Type: research