Desmoplasia Is Associated with Decreased Cytotoxic and Helper T Cells and Increased T-Cell Exhaustion in Cutaneous Squamous Cell Carcinoma
Although the vast majority of cutaneous squamous cell carcinoma (CSCC) are easily cured with surgical excision, 1 –3% of cases result in death, making deaths from CSCC similar in number to those from melanoma (Karia et al, 2014). Despite this, mechanisms governing aggressive behavior/metastasis remain largely undefined (Stang et al, 2019). Food and Drug Administration–approved immunotherapies exist for un resectable CSCCs; however, they have an approximate response rate of 50% with few complete responses and subsequently a high risk of disease-specific death (Migden et al, 2018).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Yuka Hirakawa, Qian Zhan, Sernah Essien, Kenneth K. Yu, Fadi Murad, Adriano Piris, Matthew R. Ramsey, Tobias Schatton, John A. Carucci, Chrysalyne D. Schmults Tags: Letters to the Editor Source Type: research
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