Desmoplasia Is Associated with Decreased Cytotoxic and Helper T Cells and Increased T-Cell Exhaustion in Cutaneous Squamous Cell Carcinoma

Although the vast majority of cutaneous squamous cell carcinoma (CSCC) are easily cured with surgical excision, 1 –3% of cases result in death, making deaths from CSCC similar in number to those from melanoma (Karia et al, 2014). Despite this, mechanisms governing aggressive behavior/metastasis remain largely undefined (Stang et al, 2019). Food and Drug Administration–approved immunotherapies exist for un resectable CSCCs; however, they have an approximate response rate of 50% with few complete responses and subsequently a high risk of disease-specific death (Migden et al, 2018).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research