Orchestrating neuronal activity-dependent translation via the integrated stress response protein GADD34

Trends Neurosci. 2024 Apr 12:S0166-2236(24)00058-4. doi: 10.1016/j.tins.2024.03.008. Online ahead of print.ABSTRACTIn a recent study, Oliveira and colleagues revealed how growth arrest and DNA damage-inducible protein 34 (GADD34), an effector of the integrated stress response, initiates the translation of synaptic plasticity-related mRNAs following brain-derived neurotrophic factor (BDNF) stimulation. This work suggests that GADD34 may link transcriptional products with translation control upon neuronal activation, illuminating how protein synthesis is orchestrated in neuronal plasticity.PMID:38614892 | DOI:10.1016/j.tins.2024.03.008
Source: Trends in Neurosciences - Category: Neuroscience Authors: Source Type: research