Proteome-wide assessment of human interactome as a source of capturing domain-motif and domain-domain interactions

In conclusion, all PPI datasets demonstrated significant enrichment in DMIs and DDIs (p-value <0.001), establishing Y2H and AP-MS as reliable methods for predicting these interactions. This study provides valuable insights for biologists in selecting appropriate methods for predicting DMIs, ultimately aiding in SLiM discovery.PMID:38545252 | PMC:PMC10964934 | DOI:10.1002/ccs3.12014
Source: Journal of Cell Communication and Signaling - Category: Molecular Biology Authors: Source Type: research