Anti-Tumor Potential of Post-Translational Modifications of PD-1

Curr Issues Mol Biol. 2024 Mar 6;46(3):2119-2132. doi: 10.3390/cimb46030136.ABSTRACTProgrammed cell death protein-1 (PD-1) is a vital immune checkpoint molecule. The location, stability, and protein-protein interaction of PD-1 are significantly influenced by post-translational modification (PTM) of proteins. The biological information of PD-1, including its gene and protein structures and the PD-1/PD-L1 signaling pathway, was briefly reviewed in this review. Additionally, recent research on PD-1 post-translational modification, including the study of ubiquitination, glycosylation, phosphorylation, and palmitoylation, was summarized, and research strategies for PD-1 PTM drugs were concluded. At present, only a part of PD-1/PD-L1 treated patients (35-45%) are benefited from immunotherapies, and novel strategies targeting PTM of PD-1/PD-L1 may be important for anti-PD-1/PD-L1 non-responders (poor responders).PMID:38534752 | PMC:PMC10968922 | DOI:10.3390/cimb46030136
Source: Current Issues in Molecular Biology - Category: Molecular Biology Authors: Source Type: research