Forged in the fire: Lasting impacts of inflammation on hematopoietic progenitors

Hematopoietic stem and progenitor cells (HSPCs) are multipotent and regenerative cells within the bone marrow that support the lifelong production of all the cells of the blood and immune systems. Historically thought to be a quiescent and rather inert cell type, recent studies have shown that hematopoietic stem cells (HSCs) respond to inflammatory stimuli, and these responses have a long-term impact on the overall size and composition of the HSC pool. Naturally occurring genetically variant HSC clones show differential responses to inflammatory stimuli that can influence clonal competition and contribute to clonal hematopoiesis.
Source: Experimental Hematology - Category: Hematology Authors: Tags: Review Source Type: research