Early treatment with rifaximin during epileptogenesis reverses gut alterations and reduces seizure duration in a mouse model of acquired epilepsy

In conclusion, gut-related alterations reflecting a dysfunctional state, occur during epilepsy development in a TLE mouse model. A short-term treatment with rifaximin during the early phase of the disease, reduced seizure duration and neuropathology, and reversed some intestinal changes, strengthening the therapeutic effects of gut-based therapies in epilepsy.PMID:38608741 | DOI:10.1016/j.bbi.2024.04.007

Source: Brain, Behavior, and Immunity - April 12, 2024 Category: Neurology Authors: Valentina Kebede Teresa Ravizza Silvia Balosso Rossella Di Sapia Luca Canali Sara Soldi Serena Galletti Christina Papazlatani Panagiotis A Karas Sotirios Vasileiadis Annalisa Sforzini Laura Pasetto Valentina Bonetto Annamaria Vezzani Loredana Vesci Source Type: research