Medicarpin suppresses lung cancer cell growth < em > in vitro < /em > and < em > in vivo < /em > by inducing cell apoptosis

This study was de sig ned to evaluate the anti-LC effect and reveal the underlying mechanisms of MED in vivo and in vitro. We found that MED could significantly inhibit proliferation, induce apoptosis, and cell cycle arrest of A549 and H157 cell lines. Basically, MED induced cell apoptosis of LC cells by upregu lating the expression of pro-apoptotic proteins BAX and Bak1, leading to the cleavage of caspase-3 (Casp3). Moreover, MED inhibited the proliferation of LC cells via downregulating the expression of proliferative protein Bid. Overall, MED inhibited LC cell growth in vitro and in vivo via suppressing cell proliferation and inducing cell apoptosis, suggesting the therapeutic potential of MED in treating LC.PMID:38554387 | DOI:10.2478/acph-2024-0006

Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Zongyi Shen Liqi Yin Manxia Chang Haifeng Wang Mingxuan Hao Youfeng Liang Rui Guo Ying Bi Jiansong Wang Changyuan Yu Jinmei Li Qiongli Zhai Runfen Cheng Jinku Zhang Jirui Sun Zhao Yang Source Type: research