Immunoproteasomal Processing of IsoLG-Adducted Proteins Is Essential for Hypertension

CONCLUSIONS: These studies define a previously unknown role of the immunoproteasome in DCs and ECs in CD8+ T cell activation. The immunoproteasome in DCs and ECs is critical for isoLG-adduct presentation to CD8+ T cells, and in the endothelium, this guides homing and infiltration of T cells to specific tissues.PMID:38623763 | DOI:10.1161/CIRCRESAHA.124.324068

Source: Circulation Research - April 16, 2024 Category: Cardiology Authors: N éstor de la Visitación Wei Chen Jaya Krishnan Justin P Van Beusecum Venkataraman Amarnath Elizabeth M Hennen Shilin Zhao Mohammad Saleem Mingfang Ao Sergey I Dikalov Anna E Dikalova David G Harrison David M Patrick Source Type: research