The transcription factor HMGB2 indirectly regulates APRIL expression and Gd-IgA1 production in patients with IgA nephropathy

CONCLUSION: HMGB2 expression is greater in IgAN patients than in healthy controls; it promotes APRIL expression by interacting with HMGA1, thereby inducing Gd-IgA1 overexpression and leading to IgAN.PMID:38622929 | DOI:10.1080/0886022X.2024.2338931

Source: Renal Failure - April 16, 2024 Category: Urology & Nephrology Authors: Huijuan Tian Yaling Zhai Shuaigang Sun Wenhui Zhang Zhanzheng Zhao Source Type: research