Exploring the immunomodulatory potential of Brahmi (Bacopa monnieri) in the treatment of invasive ductal carcinoma

AbstractBacopa monnieri (L) Wettst, commonly known as Brahmi, stands as a medicinal plant integral to India ’s traditional medical system, Ayurveda, where it is recognized as a “medhya rasayana”—a botanical entity believed to enhance intellect and mental clarity. Its significant role in numerous Ayurvedic formulations designed to address conditions such as anxiety, memory loss, impaired cognition, and diminished concentration underscores its prominence. Beyond its application in cognitive health, Brahmi has historically been employed in Ayurvedic practices for the treatment of inflammatory diseases, including arthritis. In contemporary biomedical research,Bacopa monnieri can attenuate the release of pro-inflammatory cytokines TNF- α and IL-6 in animal models. However, there remains a paucity of information regarding Bacopa’s potential as an anticancer agent, warranting further investigation in this domain. Based on previous findings with Brahmi (Bacopa monnieri), the current study aims to find out the role of Brahmi plant preparation (BPP) in immunomodulatory actions on IDC. Employing a specific BPP concentration, we conducted a comprehensive study using MTT assay, ELISA, DNA methylation analysis, Western blotting, ChIP, and mRNA profiling to assess BPP ’s immunomodulatory properties. Our research finding showed the role of BPP in augmenting the action of T helper 1 (TH1) cells which secreted interferon- γ (IFN-γ) which in turn activated cytotoxic T-lymphocytes...
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research