Oral tryptophan activates duodenal aryl hydrocarbon receptor in healthy subjects: a crossover randomized controlled trial

Conclusions: At the doses used in this study, oral tryptophan supplementation in humans induces microbial indole and host kynurenine metabolic pathways in the small intestine, known to be immunomodulatory. The results should prompt tryptophan intervention strategies in inflammatory conditions of the small intestine where the AhR pathway is impaired.PMID:38591144 | DOI:10.1152/ajpgi.00306.2023

Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - April 9, 2024 Category: Physiology Authors: Gaston H Rueda Natalia Causada-Calo Rajka Borojevic Andrea Nardelli Maria Ines Pinto-Sanchez Marco Constante Josie Libertucci Vidhyalakshmi Mohan Philippe Langella Linda M P Loonen Jerry M Wells Harry Sokol Elena F Verdu Premysl Bercik Source Type: research