Inhalation of 2, 4-di-tert-butylphenol-Loaded micelles suppresses respiratory syncytial virus infection in mice

In this study, we explored the anti-RSV potential of 2, 4-Di-tert-butylphenol (2, 4-DTBP), a compound derived from Houttuynia cordata Thunb. To overcome the poor solubility of 2, 4-DTBP, we encapsulated it in polymeric micelles and delivered it by inhalation. We found that 2, 4-DTBP-loaded micelles inhibited RSV infection in vitro and improved survival, lung pathology, and viral clearance in RSV-infected mice. Our results suggested that 2, 4-DTBP-loaded micelle is a promising novel therapeutic agent for RSV infection.PMID:38608838 | DOI:10.1016/j.antiviral.2024.105880

Source: Antiviral Research - April 12, 2024 Category: Virology Authors: Mingyang Guo Jianqing Peng Pengcheng Guo Qin Wang Lin Zhang Huyan Shen Fang Chen Pingping Zhang Siyu Lin Han Gao Hong Peng Rong Mou Jiandong Huang Jianxin Wang Yu-Si Luo Ke Zhang Source Type: research