Generation of integration-free human induced pluripotent stem cells from a patient with sporadic Parkinson's disease

Stem Cell Res. 2024 Apr 8;77:103416. doi: 10.1016/j.scr.2024.103416. Online ahead of print.ABSTRACTA human induced pluripotent stem cell (iPSC) line (KKUi002-A) was generated from a skin fibroblast of a 57-years-old (at sampling) male patient diagnosed with a sporadic Parkinson's disease (PD). A non-integration system was used to reprogram fibroblasts into iPSCs by an episomal vector (OCT4/p53, SOX2/KLF4, L-MYC/LIN28). The KKUi002-A iPSCs displayed typical iPSC morphology, expressed pluripotency markers, differentiated into derivatives of three germ layers, and had a normal karyotype. These PD-derived iPSCs can be used to understand the mechanism underlying PD pathogenesis.PMID:38615589 | DOI:10.1016/j.scr.2024.103416
Source: Cell Research - Category: Cytology Authors: Source Type: research