6PPDQ induces cardiomyocyte senescence via AhR/ROS-mediated autophagic flux blockage

In conclusion, our research unveils that exposure to 6PPDQ induces ROS overproduction through AhR activation, leading to disruption of autophagy flux and ultimately contributing to cardiomyocyte senescence.PMID:38604309 | DOI:10.1016/j.envpol.2024.123872

Source: Environmental Pollution - April 11, 2024 Category: Environmental Health Authors: Baoqiang Fu Tao Chen Bin Jiang Haobin Feng Ziyu Zhu Min Li Guoxing Zhang Yan Jiang Source Type: research