Evaluating the QileX-RhE skin corrosion test for chemical subcategorization in accordance with OECD TG 431

This study evaluates the QileX-RhE test system's performance for chemical subcategorization within the OECD TG 431 framework. Results demonstrate its ability to differentiate subcategories, accurately predicting 83% of UN GHS Category 1A and 73% of UN GHS Category 1B/1C chemicals with 100% sensitivity in corrosive prediction. Additionally, this study provides a comprehensive assessment of the test method's performance by employing nuanced parameters such as positive predictive value (PPV), negative predictive value (NPV), post-test odds and likelihood rations, offering valuable insights into the applicability and effectiveness of the QileX-RhE test method.PMID:38604524 | DOI:10.1016/j.tiv.2024.105816
Source: Toxicology in Vitro - Category: Toxicology Authors: Source Type: research