Apolipoprotein B - An ideal biomarker for atherosclerosis?

Indian Heart J. 2024 Mar;76 Suppl 1:S121-S129. doi: 10.1016/j.ihj.2023.12.001. Epub 2024 Apr 8.ABSTRACTThis review article describes the pathophysiological mechanisms linking Apolipoprotein B (Apo-B) and atherosclerosis, summarizes the existing evidence on Apo B as a predictor of atherosclerotic cardiovascular disease and recommendations of (inter)national treatment guidelines regarding Apo B in dyslipidemia management. A single Apo B molecule is present in every particle of very low-density lipoprotein, intermediate density lipoprotein, low density lipoprotein, and lipoprotein(a). This unique single Apo B per particle ratio makes plasma Apo B concentration a direct measure of the number of circulating atherogenic lipoproteins. This review of global evidence on Apo B as a biomarker for atherosclerosis confirms that Apo B is a single atherogenic lipid marker present in all lipids sub-fractions except HDL-C, and thus, Apo B integrates and extends the information from triglycerides and cholesterol, which could simplify and improve care for atherosclerotic cardiovascular disease.PMID:38599726 | DOI:10.1016/j.ihj.2023.12.001
Source: Indian Heart J - Category: Cardiology Authors: Source Type: research