Increased Mechanical Hypersensitivity Resulting from the Loss of Sigma-2 Receptor/Transmembrane Protein 97 Expression in Both Germline and Nociceptor-Specific Context

The Sigma-2 receptor ( σ2/TMEM97), recently identified as Tmem97, is a transmembrane protein that is located in the endoplasmic reticulum (ER) and the plasma membrane. While the literature has highlighted ligands targeting Tmem97 for anti-neuropathic effects, its involvement in inflammatory pain-like responses remains un derstudied compared to neuropathic pain. Here, we aim to characterize Tmem97-associated inflammatory pain-like behaviors using global Tmem97 knockout (KO) and conditional Tmem97 knockout mice (cKO).

Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Veronica M. Hong, Avaneesh Rade, Zubab Syed, Muhammad Saad Yousuf, Daniel J. Liebl, Stephen Martin, Theodore J. Price, Benedict J. Kolber Source Type: research