Interleukin-10-producing Monocytes Contribute to Sex Differences in Pain Resolution in Mice and Humans

Pain is closely associated with the immune system, which exhibits sexual dimorphism. For these reasons, neuro-immune interactions are suggested to drive sex differences in pain pathophysiology. However, the impact of peripheral neuro-immune interactions on sex differences in pain resolution remains limited. Here, we have shown, in both a mouse model of inflammatory pain and in humans following traumatic pain, that males had higher levels of interleukin (IL)-10 than females, which were correlated with faster pain resolution.

Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Jaewon Sim, Elizabeth O'Guin, Karli Monahan, Chiho Sugimoto, Samuel McLean, Liz Albertorio-Saez, Ying Zhao, Sophie Laumet, Andrew Dagenais, Matthew Bernard, Joseph Folger, Alfred Robison, Sarah Linnstaedt, Geoffroy Laumet Source Type: research