Single-nuclei Ribonucleic Acid Sequencing Shows Unique Transcriptomic Signatures of Rat Dorsal Root Ganglia in a Disc-associated Chronic Low Back Pain Model

Patients with disc-associated chronic low back pain (cLBP) and knee osteoarthritis (OA) often display aberrant innervation of nociceptors into the joint. Repeated stimulation or damage of nociceptors in joints can cause peripheral sensitization. Nav1.7 and Piezo2 are ion channels upregulated in dorsal root ganglia (DRGs) in painful knee OA animal models with peripheral sensitization. Despite these data, changes in DRG gene expression in human or animal models of cLBP are mostly unknown. Further, there is limited comprehensive single nucleus RNA sequencing (snRNAseq) of rat DRGs.

Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Sydney M. Caparaso, Ishwarya Sankaranarayanan, Theodore J. Price, Rebecca A. Wachs Source Type: research