Systemic Low-grade Inflammatory Markers Are Associated with Proximal Spread of Neuropathic Symptoms

Neuropathic pain is a highly prevalent condition associated with persistent and severe disability. Some patients with neuropathic pain experience symptom spread outside neuroanatomical boundaries; these patients report more severe sensory symptoms and greater disability. However, the mechanisms behind such symptom spread are not fully understood. We used carpal tunnel syndrome (CTS) as a human model system of neuropathic pain to identify differences in the concentration of serologic inflammatory mediators among patients with CTS with territorial symptoms and those with proximal symptom spread to either the elbow or shoulder/neck.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research