Role of Sensory Neuron Derived Interleukin 34 in Neonatal Nociceptive Priming

Injury to the developing peripheral nervous system can lead to prolonged hypersensitivity after repeated injury later in life; a phenomenon called neonatal nociceptive priming. After early life injury, peripheral macrophages retain epigenetic modifications and generate a more pro-inflammatory response to subsequent injury contributing to neonatal nociceptive priming. However, it is not known whether sensory neurons themselves establish similar “memories” of early life injury and therefore also contribute to priming.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research