Mebendazole induces apoptosis and inhibits migration via the reactive oxygen species-mediated STAT3 signaling downregulation in non-small cell lung cancer

CONCLUSIONS: In summary, MBZ inhibited NSCLC cell viability and migration by inducing cell apoptosis via the ROS-JAK2-STAT3 signaling pathway. These data provide a theoretical basis for the use of MBZ in treating NSCLC.PMID:38505087 | PMC:PMC10944755 | DOI:10.21037/jtd-23-1978

Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Zhipan Liang Qiuyun Chen Liuying Pan Xiaowei She Tengfei Chen Source Type: research