Epidemiologic and Clinical Clues to the Etiology of Eosinophilic Esophagitis

Immunol Allergy Clin North Am. 2024 May;44(2):145-155. doi: 10.1016/j.iac.2023.12.003. Epub 2024 Jan 13.ABSTRACTDespite the rising prevalence and incidence of eosinophilic esophagitis (EoE), the etiology and pathophysiology remain unknown. Studies to date suggest that complex interactions between genetic and environmental risk factors result in the development and presentation of disease. Examining environmental factors both in the early life and later life exposures offers potential clues for the development of EoE, although challenges exist in making causal inferences due to diagnostic delay and access, ascertainment biases, and misclassification of cases. The authors review studies supporting early life factors as etiologic factors in the development of EoE.PMID:38575214 | PMC:PMC11003716 | DOI:10.1016/j.iac.2023.12.003
Source: The Medical Clinics of North America - Category: General Medicine Authors: Source Type: research