Prolonged Warm Ischemia and Cold Storage Promote Myocardial Edema in Human Hearts Donated After Circulatory Death via Accumulation of Cyclic Guanosine Monophosphate and Aquaporin 1

Purpose: Significant myocardium edema (ME) is often noted in human hearts donated after circulatory death (DCD), which might contribute to graft dysfunction. The underlying mechanism of ME in DCD hearts was poorly understood. Since activation of cyclic guanosine monophosphate (cGMP) and aquaporin 1 (AQP1) is known to play an important role in tissue edema formation, we measured AQP1, cGMP, and ME in DCD hearts to see if they were correlated, especially with different warm ischemia time (WIT) and subsequent cold storage time(CST).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research