Early Post-Transplant Airway Il-5 and Eosinophilia Are Associated with Baseline Lung Allograft Dysfunction and Impaired Allograft Survival

Purpose: Baseline lung allograft dysfunction (BLAD) has been recently described as the failure to attain normal lung function post-lung transplantation. Among bilateral lung transplant recipients (LTRs), BLAD within the first-year post-transplant (Tx) has been associated with impaired survival; however, the pathophysiology of BLAD remains poorly understood. Herein, we compared early airway inflammatory mediators between LTRs with and without BLAD at 1-year post-Tx; this pointed us specifically to airway IL-5 and allograft eosinophilia as risk factors for BLAD.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research