How Well Does the Molecular Microscope Diagnostic System (MMDx) Correlate with Traditional Pathologic Biopsy Interpretation in a Pediatric Heart Transplant Population?

Purpose: Histologic evaluation of endomyocardial biopsies (EMB) is the gold-standard for diagnosis of rejection post heart transplant (HT), but the methodology is subject to interobserver variability and sampling error. The molecular microscope diagnostic system (MMDx) analyzes RNA transcripts from EMB tissue to differentiate quiescent allograft tissue from that with rejection/injury. While MMDx results have been described in adult HT cohorts, less is known about its utility in pediatric patients which differ regarding indications for HT, degree of anti-HLA sensitization, and post HT immunosuppression.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research