Triangular Associations Between the Lower Airway Microbiome, Host Immune Tone, and Primary Graft Dysfunction in Lung Transplantation

Purpose: Lower airway enrichment with oral commensals has been previously demonstrated in grade 3 (severe) primary graft dysfunction (PGD) occurring after lung transplantation (LT). We hypothesized that this dysbiotic signature is present across all PGD grades, including more milder forms, and is associated with a distinct host inflammatory endotype.

Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , N.C. Nelson, K.K. Wong, I.J. Mahoney, B.G. Wu, T. Malik, D. Rudym, M.B. Lesko, S. Qayum, S.H. Chang, J.C. Chan, T.C. Geraci, T.C. Lewis, F.A. Tiripicchio, Y. Li, P. Pamar, J. Schnier, R. Singh, D.E. Collazo, M. Chang, Y. Kyeremateng, C. McCormick, S. Pa Source Type: research