Micro-RNA Biomarkers of Allograft Rejection in Pediatric Heart Transplantation

Purpose: Historically, endomyocardial biopsy (EMB) has been the standard for surveillance and diagnosis of rejection after heart transplantation. EMB is invasive and distressing for pediatric heart transplant (PHT) recipients. In adults, non-invasive, molecular evaluation of rejection has eliminated the need for many surveillance EMBs by detecting allograft injury suggestive of acute cellular rejection (ACR) or antibody-mediated rejection (AMR). Our previous work identified blood-based microRNAs (miRs) that accurately discriminated ACR and AMR in adults.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research