Exosomal Microrna-17-5p and Microrna-150-5p in Plasma as Diagnostic Markers of Chronic Lung Allograft Dysfunction After Lung Transplantation

Purpose: Circulating microRNAs (miRNAs) have been shown to be potential biomarkers for chronic lung allograft dysfunction (CLAD) after lung transplantation (LT). However, circulating miRNAs consist of miRNAs contained within apoptotic bodies which are released during cell death, protein- or lipid-mediated miRNAs, and exosomal miRNAs (exo-miRNAs) which are actively secreted by living cells. Although exo-miRNAs are involved in the pathogenesis of various diseases, little information has been available about the role of exo-miRNAs in the development of CLAD after LT.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research