CD40 Ligand and NKG7 Mark Distinct Alloeffector CD4 T Cell Populations in Acute Lung Rejection

Purpose: Lung transplantation remains the only therapeutic option for select patients with end-stage lung diseases. Acute cellular rejection (ACR) is the major risk factor for chronic lung allograft dysfunction (CLAD), the predominant barrier for long-term survival in lung transplant recipients (LTRs). However, little is known about the role of donor specific CD4+T cell responses in ACR and the potential impact on the development of CLAD in LTRs.

Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , M. Snyder, S. Lieber, K. Devonshire, C. Iasella, M. Sciullo, S. Hannan, R. Koshy, R. Burke, J. Sembrat, J. Pilewski, C. Hage, P. Sanchez, K. Chen, J. McDyer Source Type: research