Unraveling the Gordian knot of coronary pressure-flow autoregulation
The coronary circulation has the inherent ability to maintain myocardial perfusion constant over a wide range of perfusion pressures. The phenomenon of pressure-flow autoregulation is crucial in response to flow-limiting atherosclerotic lesions which diminish coronary driving pressure and increase risk of myocardial ischemia and infarction. Despite well over half a century of devoted research, understanding of the mechanisms responsible for autoregulation remains one of the most fundamental and contested questions in the field today.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Johnathan D. Tune, Cooper M. Warne, Salman I. Essajee, Selina M. Tucker, C. Alberto Figueroa, Gregory M. Dick, Daniel A. Beard Tags: Review article Source Type: research