Single-cell characterisation of tissue homing CD4  + and CD8 + T cell clones in immune-mediated refractory arthritis

CONCLUSIONS: Our findings suggest that the local environment in the synovium drives the proliferation of activated cytotoxic T cells, and both CD4 + and CD8 + T cells may contribute to tissue destruction and disease pathogenesis.PMID:38594612 | DOI:10.1186/s10020-024-00802-1

Source: Molecular Medicine - April 9, 2024 Category: Molecular Biology Authors: Dipabarna Bhattacharya Jason Theodoropoulos Katariina Nurmi Timo Juutilainen Kari K Eklund Riitta Koivuniemi Tiina Kelkka Satu Mustjoki Tapio L önnberg Source Type: research