Engeletin alleviates depressive-like behaviours by modulating microglial polarization via the LCN2/CXCL10 signalling pathway

In conclusion, engeletin can alleviate CSDS-induced depressive-like behaviours by regulating the LCN2/CXCL10 pathway and thereby altering the polarization of microglia. These data suggest that the antidepressant effects of engeletin are correlated with the polarization of microglia, highlighting a potential avenue for future design of antidepressant strategies that specifically target the microglia.PMID:38597406 | DOI:10.1111/jcmm.18285

Source: Molecular Medicine - April 10, 2024 Category: Molecular Biology Authors: Jie Zhang Zheng Song Yanchao Huo Guangqiang Li Liming Lu Chuanmei Wei Shuping Zhang Xinfu Gao Xingyue Jiang Yangyang Xu Source Type: research