Dual inhibition of oxidative phosphorylation and glycolysis to enhance cancer therapy

This study not only provided a new path for dual inhibition of both mitochondrial OXPHOS and glycolytic metabolisms with a novel α-TOS-functionalized metallodrug, but also further demonstrated that the mitochondrial-relevant therapy could be effective in enhancing the anticancer performance.PMID:38583247 | DOI:10.1016/j.bioorg.2024.107325
Source: Bioorganic Chemistry - Category: Chemistry Authors: Source Type: research